1344159 - Pharmacokinetics of Tranexamic Acid in Patients Undergoing Cardiac Surgery
نویسندگان
چکیده
Introduction: Tranexamic acid (TXA) is routinely used during cardiac surgical procedures involving cardiopulmonary bypass (CPB) in order to reduce blood loss [1]. Although the optimum dose of TXA has been a subject of debate, a dosing regimen also sometimes referred to as the BART dose remains a popular choice for high-risk cardiac surgery [2]. The pharmacokinetics of TXA during the perioperative period with this antifibrinolytic dose has not been studied. The primary objective of this study was to measure the TXA plasma concentrations following infusion of the BART dose during cardiac surgery with the use of CPB. The secondary objectives of this study were to ascertain if observed TXA concentrations were within the suggested target range to allow optimal inhibition of tissue plasminogen activator (TPA) and to evaluate elimination kinetics of TXA in the postoperative period following discontinuation of the infusion
منابع مشابه
Effectiveness of Moderate Acute Normovolemic Hemodilution Combined with Tranexamic Acid on the Reduction of Allogenic Blood Transfusion in Patients Undergoing Off-pump Coronary Artery Bypass
Introduction: There are different approaches to reduce the amount of blood loss and allogenic transfusion in cardiac surgery. Regarding this, the present study aimed to evaluate the blood sparing effect of acute normovolemic hemidilution (ANH) combined with intrao-perative tranexamic acid in patients undergoing off-pump coronary artery bypass (OPCAB).Material and Methods: This study was conduct...
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